Knee Arthritis

Knee Arthritis Clinic

Clinics In Harley Street - London, Bedford & Wellingborough 

offering non-surgical solutions FOR pain relief, improved mobility and 

Patient Reviews
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           At ProHealth Clinic we offer the UK's most comprehensive non-surgical treatment approach for knee osteoarthritis, having built our reputation on achieving results when all else has failed. Research is now showing that only a fraction of cases of knee osteoarthritis are related to an individuals genetics. The majority of cases are caused by a combination of biomechanical misalignments, tendon/ligament/muscle imbalances, oxidative stress, environmental toxins and nutrient deficiencies.
Many patients who have come to see us at ProHealth Clinic have previously tried other regenerative treatments with little or no success. Those who have had success report the benefits were only temporary. Often the reason why is because the treatment wasn't part of an integrated program that takes into account the dynamic relationship between all the structures of the knee and their role in contributing to the pain experienced with arthritis.
"We're beginning to understand that osteoarthritis is a disease of the entire joint," explains Dr. Antonios Aliprantis, associate Professor at Harvard Medical School and Director of the Osteoarthritis Center at Brigham Hospital. "Much of the research over the last 20 or 30 years has focused on cartilage as the target. But we're beginning to realize that there are important changes happening in the bone underneath the cartilage, and in the joint lining itself—the synovium. As we begin to understand osteoarthritis as a disease of the entire joint, new treatment targets will emerge."
For example, when cartilage starts to wear down in an individuals knee, the whole joint becomes unstable, causing the muscles, ligaments, tendons and the synovium that attaches into the knee to have to work harder to stop the joint giving way. In this process of having to work harder, these structures start to become painful and weak, causing further instability alongside misalignments of the knee cap. This is one of the primary reasons why individuals will experience poor results with previous treatments, as the structure actually causing the pain in the knee hasn't formally been identified during examinations. Our clinical audits show that in 72% of patients that come into our clinic with knee arthritis, we identify that their pain isn't actually coming from the bones of the joint rubbing against each other. The pain is in fact coming from one or several of the other previously stated structures within or around the knee, that have had to work harder to stabilise the joint due to the cartilage wear.
We perform ultrasound imaging on the knee to confirm which of these structures are damaged and causing an individuals pain. Unfortunately many doctors and consultants are unaware that other structures within the knee are likely to be the source of an individuals pain with osteoarthritis. Too often they assume the pain is from the bones rubbing against each other based on x-ray results, and then too quickly conclude that knee replacement is the best option. This is another reason why many patients undergo knee replacement surgery and wonder why they are still in pain after the operation.
At our clinic we use a combination of diagnostic bio-mechanical scanning, ultrasound imaging and orthopeadic testing protocols to first identify where the pain is coming from, and then put together a tailored integrated treatment program to not only repair and strengthen the cartilage, but also to help address tendon, ligament and muscle damage. Even in patients whose x-rays have shown limited cartilage left, our treatment program is still able to achieve a reduction in pain and inflammation. Based on digital muscle strength testing we perform as part of each examination, we will also prescribe a patient a tailored strength and conditioning program to help reinforce the muscles and tendons around the knee, to both enhance and sustain the results from the treatment program. Our program involves the following: 
Consultation and Examinations  
- Full Medical History 
- Full Bio-Mechanical Scan & Analysis
- Diagnostic Ultrasound Imaging of the supporting structures of the knee
- Dynamic Orthopaedic Movement Tests
- Digital Muscle Strength Testing
- Bio-Energetic Testing and Nutritional Analysis (if required)
- Report of Findings
Treatment Program
- Prolozone Injection Therapy
- Physical Therapy
- Strength and Conditioning Program
- Tailored Nutritional Prescription 

Prolozone Injection Therapy

             In recent years Prolozone injections have been making a name for themselves within the medical community for their studied ability to prevent risky knee replacement surgery. Research has proven their pain relieving, anti-inflammatory and regenerative properties for individuals suffering from knee arthritis. It was pioneered by an American Doctor, Dr Frank Shallenberger. The name "Prolozone Therapy" is derived from the Latin word "prolix" which means to proliferate, regenerate and rebuild. The natural treatment uses Medical Ozone and specific nutrients to cause the regeneration and rebuilding of cartilage, alongside other structures within the knee that have suffered degeneration or become painful and weak. The reason cartilage degenerates is because it is one of the only structures in the body that doesn't have a blood supply. When you cut your skin, it heals over and grows back as it's got a blood supply, unfortunately cartilage doesn't have that luxury. Oxygen is the main component within our blood that helps body tissue to heal and regenerate. Medical Ozone is a concentrated form of oxygen. The injected Medical Ozone has been shown in studies to stimulate stem cell production; these are the primary cells the body uses to repair and regenerate damaged body tissue, including cartilage. The stimulated stem cells are deposited in the form of mesenchymal progenitor cells called chondroblasts, which then convert into chondrocytes. These cells are the pre-curser building blocks of cartilage. Prolozone injections have shown to not only reduce pain, inflammation and stimulate cartilage growth, but also to repair and strengthen the ligaments within the knee, which have been put under additional strain from the instability arthritis causes within a joint. This increase in cellular repair activity both strengthens and stabilises the knee joint as a whole, and in the majority of cases significantly reduces pain and stiffness. Prolozone is naturally anti-bacterial, so deemed one of the safest injections on offer within medicine. Its impeccable safety record has been the reason why thousands of doctors and practitioners around the world are now adopting it as an effective, non-invasive alternative to risky knee replacement surgery.

Scientific studies on Medical Ozone for Knee Osteoarthritis:
REVIEW STUDY: Medical Ozone as a Feasible Future Treatment in Osteoarthritis of the Knee
CONCLUSION:  There is long term evidence (four decades of clinical use) of the use of Medical Ozone on many diseases and especially on treating musculoskeletal disorders such as knee osteoarthritis. Medical Ozone is able to inhibit inflammatory cytokines, MMP (mineral metalloproteinases), NO (nitric oxide), PGs and to stimulate anti-inflammatory cytokines, growing factors, chondrocytes and stem cells. Medical Ozone diminishes inflammation and favours the trophism, vascularisation and repair of articular cartilage and subchondral bone. The action of Medical Ozone over different targets on knee osteoarthritis postulates it as a promising and wonderful therapeutic weapon capable to diminish pain, articular destruction and recover function and quality of life. Because of all the expected potentials attributed to Medical Ozone therapy in different medical specialties (including knee osteoarthritis), there is the hope that Medical Ozone therapy will be part of medicine in all public hospitals as it is in ours.
STUDY: Medical Ozone Improves Pain Relief, Function and Quality of Life in Patients with Knee Osteoarthritis: A Prospective Quasi-Experimental Before-After Study
RESULTS: Our findings indicating that after 3 sessions of injections (1 per week) of 10 mL Medical Ozone at a concentration of 30 ug / mL, a success rate of 80% in pain and stiffness reduction, and functional capacity improvement measured by the WOMAC scale. Medical Ozone is a safe and effective treatment able to significantly reduce pain and stiffness, and to improve function, as measured by VAS/WOMAC scales, in patients with knee osteoarthritis. The results of this study show a good level of evidence as well as a good grade of recommendation, which allows us to use Medical Ozone as a conservative therapeutic option in the treatment of osteoarthritis of the knee.  
STUDY: Medical ozone therapy as a potential treatment modality for regeneration of damaged articular cartilage in osteoarthritis
RESULTS: "Medical Ozone is an efficient therapy in the treatment of damaged articular cartilage in Osteoarthritis. Medical Ozone inhibits the inflammatory milieu which effects the cartilage matrix and induces apoptosis of chondrocytes in osteoarthritis. It produces its beneficial effects by normalizing the cellular redox balance and through the actions of cytokines."
STUDY: The Application of Medical Ozone Therapy in patients with Knee Osteoarthritis
RESULTS: "Combined ozone therapy diminished the oxidative stress, achieving an intra-articular redox balance, as well as a significant reduction of pain, with a maintained satisfactory response in 80% of patients in 1-year follow-up. An increase in the quality of life of patients with knee osteoarthritis was observed, without the presence of side effects.
STUDY: Role of intra-articular medical ozone in osteoarthritis of the knee for functional and symptomatic improvement
RESULTS: "Intra-articular Medical Ozone injections achieved an 80% success rate of a reduction in pain and stiffness which was still apparent during a 6 month patient follow-up. This was compared to only a 60% percent success rate achieved by prednisolone (corticosteroid) injections."
STUDY: Therapeutic Effect of Low Concentration Medical Ozone on Knee Osteoarthritis
RESULTS: 62 patients presented the symptoms of pain and activity limitation of knee joint and the diagnosis was verified by radiological examination. They were treated by injection of medical ozone(concentration 35μg/mL). 21 males and 41 females with average age of 65.5 years were included. The VAS and HSS score system was used with a success rate of symptom reduction in 72% of patients. In conclusion the injection of low concentration medical ozone into the articular cavity of the knee was a safe and effective method for treating knee osteoarthritis.

Bio-mechanical Assessment & Physical Therapy

An estimated 4.1 million people in the UK suffer from knee arthritis, many of which are under the false impression that the cause of the condition is either genetic or from years of overuse. In the time we've been specialising in knee arthritis we've found the majority of cases of the condition to be as a result of a subtle misalignment in the bio-mechanics of either the pelvis or ankles that influences the angle of the knee. This misalignment causes either the outside or inside of a knee joint to become overloaded, eventually wearing the cartilage down on that side. So the cause of 'years of overuse' is partly true, but very much due to the overuse of one side of the knee from becoming overloaded. Once these misalignments are identified and corrected with the specialist physical therapy that we provide alongside the injections, the affected knee will return back to experiencing an even pressure across both sides of the joint, compared to it all going through one side of the joint. Correcting these misalignments can significantly enhance the injections ability to reduce pain, improve mobility and halt the progression of knee arthritis alongside prevent arthritis in neighbouring joints such as the hips and ankles. We use the latest computerised bio-mechanical analysis technology to accurately assess and analyse these misalignments. Alongside physical therapy for the knee we also treat other parts of the body that have been effected from any limping the knee arthritis may have caused, commonly hip and back pain. 

Ultrasound Imaging

During our clinical assessments we use ultrasound imaging to help identify any damage and dysfunction with the supporting structures of the knee: muscles, tendons, ligaments and bursa. Damage to the supporting structures of the knee can often contribute to an individuals symptoms and the level of pain they experience. By identifying and addressing this damage with our treatments we can help to prevent any need for surgery in the future. 

Nutritional Analysis and Bio-energetic Testing

Research produced by the University of Surrey has confirmed that an individuals nutritional status plays a large role in cartilage degeneration, pain and inflammation. Nutrition and the things we eat provide the building blocks to cartilage and also help mediate levels of inflammation. Research has shown many people suffering from arthritis are low in many of these key nutrients that help to combat the debilitating symptoms of arthritis and maintain the health of cartilage. Using state-of-the-art computerised bio-energetic testing we are able to accurately identify all the specific nutrients that an individual is deficient in, alongside identify any other physiological factors contributing to their arthritis. This allows us to recommend certain supplements and provide dietary advice specific to an individuals body and nutritional status. 

Lead scientist at the University of Surrey, Prof Ali Mobasheri said: "For too long osteoarthritis has been known as the 'wear and tear disease' and it has been assumed that it is part and parcel of getting older. However, this is not the case and what we have learnt is that we can control and prevent the onset of this painful condition."

Safety and Efficacy

The International Ozone Association reports that these treatments have been successfully used in Europe for over 50 years by over 10,000 doctors and practitioners with over 3000 medical references for the use and safety of Medical Ozone in medicine. We use ultrasound imaging to help guide our injections for increased accuracy and efficacy.
Patient Reviews
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PLEASE NOTE: These treatments are only available at our London and Bedford Clinics. 
Feel free to contact us if you have any questions.
Call ProHealth Clinic today on
0800 107 3238
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