In recent years Prolozone injections have been making a name for themselves within the medical community for their studied ability to prevent risky knee replacement surgery. Research has proven their pain relieving, anti-inflammatory and regenerative properties for individuals suffering from knee arthritis. It was pioneered by an American Doctor, Dr Frank Shallenberger. The name "Prolozone Therapy" is derived from the Latin word "prolix" which means to proliferate, regenerate and rebuild. The natural treatment uses Medical Ozone and specific nutrients to cause the regeneration and rebuilding of cartilage, alongside other structures within the knee that have suffered degeneration or become painful and weak. The reason cartilage degenerates is because it is one of the only structures in the body that doesn't have a blood supply. When you cut your skin, it heals over and grows back as it's got a blood supply, unfortunately cartilage doesn't have that luxury. Oxygen is the main component within our blood that helps body tissue to heal and regenerate. Medical Ozone is a concentrated form of oxygen. The injected Medical Ozone has been shown in studies to stimulate stem cell production; these are the primary cells the body uses to repair and regenerate damaged body tissue, including cartilage. The stimulated stem cells are deposited in the form of mesenchymal progenitor cells called chondroblasts, which then convert into chondrocytes. These cells are the pre-curser building blocks of cartilage. Prolozone injections have shown to not only reduce pain, inflammation and stimulate cartilage growth, but also to repair and strengthen the ligaments within the knee, which have been put under additional strain from the instability arthritis causes within a joint. This increase in cellular repair activity both strengthens and stabilises the knee joint as a whole, and in the majority of cases significantly reduces pain and stiffness. Prolozone is naturally anti-bacterial, so deemed one of the safest injections on offer within medicine. Its impeccable safety record has been the reason why thousands of doctors and practitioners around the world are now adopting it as an effective, non-invasive alternative to risky knee replacement surgery.
Scientific studies on Medical Ozone for Knee Osteoarthritis:
Medical Ozone as a Feasible Future Treatment in Osteoarthritis of the Knee
There is long term evidence (four decades of clinical use) of the use of Medical Ozone on many diseases and especially on treating musculoskeletal disorders such as knee osteoarthritis. Medical Ozone is able to inhibit inflammatory cytokines, MMP (mineral metalloproteinases), NO (nitric oxide), PGs and to stimulate anti-inflammatory cytokines, growing factors, chondrocytes and stem cells. Medical Ozone diminishes inflammation and favours the trophism, vascularisation and repair of articular cartilage and subchondral bone. The action of Medical Ozone over different targets on knee osteoarthritis postulates it as a promising and wonderful therapeutic weapon capable to diminish pain, articular destruction and recover function and quality of life. Because of all the expected potentials attributed to Medical Ozone therapy in different medical specialties (including knee osteoarthritis), there is the hope that Medical Ozone therapy will be part of medicine in all public hospitals as it is in ours.
Medical Ozone Improves Pain Relief, Function and Quality of Life in Patients with Knee Osteoarthritis: A Prospective Quasi-Experimental Before-After Study
Our findings indicating that after 3 sessions of injections (1 per week) of 10 mL Medical Ozone at a concentration of 30 ug / mL, a success rate of 80% in pain and stiffness reduction, and functional capacity improvement measured by the WOMAC scale. Medical Ozone is a safe and effective treatment able to significantly reduce pain and stiffness, and to improve function, as measured by VAS/WOMAC scales, in patients with knee osteoarthritis. The results of this study show a good level of evidence as well as a good grade of recommendation, which allows us to use Medical Ozone as a conservative therapeutic option in the treatment of osteoarthritis of the knee.
Medical ozone therapy as a potential treatment modality for regeneration of damaged articular cartilage in osteoarthritis
"Medical Ozone is an efficient therapy in the treatment of damaged articular cartilage in Osteoarthritis. Medical Ozone inhibits the inflammatory milieu which effects the cartilage matrix and induces apoptosis of chondrocytes in osteoarthritis. It produces its beneficial effects by normalizing the cellular redox balance and through the actions of cytokines."
The Application of Medical Ozone Therapy in patients with Knee Osteoarthritis
RESULTS: "Combined ozone therapy diminished the oxidative stress, achieving an intra-articular redox balance, as well as a significant reduction of pain, with a maintained satisfactory response in 80% of patients in 1-year follow-up. An increase in the quality of life of patients with knee osteoarthritis was observed, without the presence of side effects.
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Role of intra-articular medical ozone in osteoarthritis of the knee for functional and symptomatic improvement
"Intra-articular Medical Ozone injections achieved an 80% success rate of a reduction in pain and stiffness which was still apparent during a 6 month patient follow-up. This was compared to only a 60% percent success rate achieved by prednisolone (corticosteroid) injections."
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Therapeutic Effect of Low Concentration Medical Ozone on Knee Osteoarthritis
62 patients presented the symptoms of pain and activity limitation of knee joint and the diagnosis was verified by radiological examination. They were treated by injection of medical ozone(concentration 35μg/mL). 21 males and 41 females with average age of 65.5 years were included. The VAS and HSS score system was used with a success rate of symptom reduction in 72% of patients. In conclusion the injection of low concentration medical ozone into the articular cavity of the knee was a safe and effective method for treating knee osteoarthritis.
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